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Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. (Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM. purity: 99%
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Recombinant mouse Semaphorin-4A produced in HEK293 cells with a C-terminal 6xHis tag. The lyophilized protein is supplied in small research quantities (10 μg) at ≥95% purity and is intended for in vitro binding studies, antibody validation, and functional assays; follow reconstitution and storage instructions from the manufacturer.
Produced in HEK293 mammalian expression system.
C-terminal 6xHis tag for detection and purification.
Purity ≥95% as determined by reducing SDS-PAGE.
Reported molecular weight approximately 67-95 kDa.
Provided in research-scale quantities suitable for assay development.
Store and aliquot at -20°C or -80°C for extended stability.
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CU CPT 4a (CAS 1279713-77-7) is a small-molecule inhibitor that selectively targets Toll-like receptor 3 (TLR3) It disrupts TLR3-mediated signaling by blocking the interaction between TLR3 and double-stranded RNA (dsRNA) thereby suppressing downstream pathways In RAW 264 7 cells CU CPT 4a demonstrates an IC50 of 3 44 M for TLR3 inhibition and significantly reduces the production of pro-inflammatory cytokines including TNF- and IL-1 In murine models administration of CU CPT 4a has been shown to protect crypt cells from death and decrease the severity of radiation-induced gastrointestinal syndrome This compound is valuable for research into TLR3-related inflammatory and radiation injury mechanisms
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Molecular sieves are crystalline metal aluminosilicates having a 3-dimensional interconnecting network of silica and alumina tetrahedra. Natural water of hydration is removed from this network by heating to produce uniform cavities which selectively adsorb molecules of a specific size. The 3A form is made by substituting potassium cations for the inherent sodium ions of the 4A structure reducing the effective pore size to ~3A… excluding diameter 3A… e.g. ethane. The 4 to 8-mesh type is normally used in gas-phase applications. Molecular sieves are considered a universal drying agent in polar and nonpolar media.
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Recombinant rat Semaphorin-3A is supplied lyophilized and formulated for stability; it is expressed in E. coli with an N-terminal 6xHis tag and is intended for research on axon guidance and semaphorin signaling.
Recombinant rat semaphorin-3a expressed in E. coli with an N-terminal 6xHis tag.
Approximately 90.6 kDa molecular weight, >90% purity by reducing SDS-PAGE.
Lyophilized formulation containing trehalose to enhance shelf stability.
Stable at -20°C for up to two years; reconstituted stability 4°C for 1 week or -20°C for longer with carrier protein.
Do not reconstitute below 100 μg/mL in ddH2O to maintain recommended concentration.
Intended for in vitro studies of axon guidance and semaphorin signaling pathways.
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Nutlin-3a (Rebemadlin) is a research-grade small molecule that antagonizes MDM2, disrupting the MDM2-p53 interaction to stabilize wild-type p53 and trigger apoptosis and autophagy. It is used in preclinical studies to probe p53-dependent cancer biology and cellular stress responses.
Inhibits MDM2-p53 interaction.
Stabilizes wild-type p53 protein.
Induces apoptosis and autophagy in p53-competent cells.
Reported IC50 approximately 90 nM in biochemical assays.
Molecular formula C30H30Cl2N4O4; molecular weight 581.49 g/mol.
Suitable for in vitro and preclinical research applications.
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